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Cytosine base modifications regulate DNA duplex stability and metabolism

Rausch, Cathia ; Zhang, Peng ; Casas-Delucchi, Corella S ; Daiß, Julia L ; Engel, Christoph ; Coster, Gideon ; Hastert, Florian D ; Weber, Patrick ; Cardoso, M Cristina



Abstract

DNA base modifications diversify the genome and are essential players in development. Yet, their influence on DNA physical properties and the ensuing effects on genome metabolism are poorly understood. Here, we focus on the interplay of cytosine modifications and DNA processes. We show by a combination of in vitro reactions with well-defined protein compositions and conditions, and in vivo ...

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