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Transcriptional Profiling Identifies Upregulation of Neuroprotective Pathways in Retinitis Pigmentosa

Bielmeier, Christina B. ; Roth, Saskia ; Schmitt, Sabrina I. ; Boneva, Stefaniya K. ; Schlecht, Anja ; Vallon, Mario ; Tamm, Ernst R. ; Ergün, Süleyman ; Neueder, Andreas ; Braunger, Barbara M.


Hereditary retinal degenerations like retinitis pigmentosa (RP) are among the leading causes of blindness in younger patients. To enable in vivo investigation of cellular and molecular mechanisms responsible for photoreceptor cell death and to allow testing of therapeutic strategies that could prevent retinal degeneration, animal models have been created. In this study, we deeply characterized ...


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