Macrophages inhibit and enhance endometriosis depending on their origin

Hogg, Chloe ; Panir, Kavita ; Dhami, Priya ; Rosser, Matthew ; Mack, Matthias ; Soong, Daniel ; Pollard, Jeffrey W. ; Jenkins, Stephen J. ; Horne, Andrew W. ; Greaves, Erin

Alternative Links zum Volltext:DOI Verlag

Bibliographische Daten exportieren

Zusammenfassung

Macrophages are intimately involved in the pathophysiology of endometriosis, a chronic inflammatory disorder characterized by the growth of endometrial-like tissue (lesions) outside the uterus. By combining genetic and pharmacological monocyte and macrophage depletion strategies we determined the ontogeny and function of macrophages in a mouse model of induced endometriosis. We demonstrate that ...