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Detection of Genomically Aberrant Cells within Circulating Tumor Microemboli (CTMs) Isolated from Early-Stage Breast Cancer Patients

Silvestri, Marco ; Reduzzi, Carolina ; Feliciello, Giancarlo ; Vismara, Marta ; Schamberger, Thomas ; Köstler, Cäcilia ; Motta, Rosita ; Calza, Stefano ; Ferraris, Cristina ; Vingiani, Andrea ; Pruneri, Giancarlo ; Daidone, Maria Grazia ; Klein, Christoph A. ; Polzer, Bernhard ; Cappelletti, Vera


Simple Summary Distant metastases derive from the shedding and dissemination of single cancer cells (CTCs) or circulating tumor emboli (CTMs) into circulation. Previous studies on CTMs were mainly run in patients with metastatic disease; however, we observed that CTMs are more frequently detected in patients with early-stage breast cancer. Here, we collected single CTMs and their relative primary ...


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