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Prognostic value of the micronucleus assay for clinical endpoints in neoadjuvant radiochemotherapy for rectal cancer

Dröge, Leif Hendrik ; Hennies, Steffen ; Lorenzen, Stephan ; Conradi, Lena-Christin ; Quack, Henriette ; Liersch, Torsten ; Helms, Christian ; Frank, Miriam Alice ; Schirmer, Markus Anton ; Rave-Fränk, Margret ; Beißbarth, Tim ; Wolff, Hendrik Andreas



Zusammenfassung

BackgroundThe question whether lymphocyte radiosensitivity is representative of patients' response to radiotherapy (RT) remains unsolved. We analyzed lymphocyte cytogenetic damage in patients who were homogeneously treated with preoperative radiochemotherapy (RCT) for rectal cancer within clinical trials. We tested for interindividual variation and consistent radiosensitivity after in-vivo and ...

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