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Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p

Ahonen, Maria A. ; Asghar, Muhammad Yasir ; Parviainen, Suvi J. ; Liebisch, Gerhard ; Höring, Marcus ; Leidenius, Marjut ; Fischer-Posovszky, Pamela ; Wabitsch, Martin ; Mikkola, Tomi S. ; Törnquist, Kid ; Savolainen-Peltonen, Hanna ; Haridas, P.A. Nidhina ; Olkkonen, Vesa M.


MicroRNA-221-3p (miR-221-3p) is associated with both metabolic diseases and cancers. However, its role in terminal adipocyte differentiation and lipid metabolism are uncharacterized. miR-221-3p or its inhibitor was transfected into differentiating or mature human adipocytes. Triglyceride (TG) content and adipogenic gene expression were monitored, global lipidome analysis was carried out, and ...


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