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The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer

Dijk, Nick van ; Gil-Jimenez, Alberto ; Silina, Karina ; Montfoort, Maurits L. van ; Einerhand, Sarah ; Jonkman, Lars ; Voskuilen, Charlotte S. ; Peters, Dennis ; Sanders, Joyce ; Lubeck, Yoni ; Broeks, Annegien ; Hooijberg, Erik ; Vis, Daniel J. ; Broek, Maries van den ; Wessels, Lodewyk F. A. ; Rhijn, Bas W. G. van ; Heijden, Michiel S. van der


Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power. A comprehensive overview of the tumor immune contexture, including Tertiary Lymphoid structures (TLS), is needed to better understand the immunotherapy response in UC. We analyzed tumor sections by quantitative multiplex ...


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