Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation

URN to cite this document:: urn:nbn:de:bvb:355-epub-565387
DOI to cite this document:: 10.5283/epub.56538

Dirks, Meike ; Buchert, Ralph ; Wirries, Ann-Katrin ; Pflugrad, Henning ; Grosse, Gerrit M.

; Petrusch, Carlotta ; Schütze, Christian ; Wilke, Florian ; Mamach, Martin ; Hamann, Linda ; Langer, Laura B. N. ; Ding, Xiao-Qi ; Barg-Hock, Hannelore ; Klempnauer, Jürgen ; Wetzel, Christian H.

; Lukacevic, Mario ; Janssen, Eike ; Kessler, Mariella ; Bengel, Frank M. ; Geworski, Lilli ; Rupprecht, Rainer ; Ross, Tobias L. ; Berding, Georg ; Weissenborn, Karin

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Date of publication of this fulltext: 29 Feb 2024 12:28

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Abstract

Purpose Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) imaging with the translocator protein (TSPO) ligand F-18-GE-180 to evaluate microglial activation in liver-transplanted patients under different regimens of immunosuppression. Methods ...