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Reduced microglia activity in patients with long-term immunosuppressive therapy after liver transplantation

Dirks, Meike ; Buchert, Ralph ; Wirries, Ann-Katrin ; Pflugrad, Henning ; Grosse, Gerrit M. ; Petrusch, Carlotta ; Schütze, Christian ; Wilke, Florian ; Mamach, Martin ; Hamann, Linda ; Langer, Laura B. N. ; Ding, Xiao-Qi ; Barg-Hock, Hannelore ; Klempnauer, Jürgen ; Wetzel, Christian H. ; Lukacevic, Mario ; Janssen, Eike ; Kessler, Mariella ; Bengel, Frank M. ; Geworski, Lilli ; Rupprecht, Rainer ; Ross, Tobias L. ; Berding, Georg ; Weissenborn, Karin


Purpose Calcineurin inhibitors (CNI) can cause long-term impairment of brain function. Possible pathomechanisms include alterations of the cerebral immune system. This study used positron emission tomography (PET) imaging with the translocator protein (TSPO) ligand F-18-GE-180 to evaluate microglial activation in liver-transplanted patients under different regimens of immunosuppression. Methods ...


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