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Prognostic Role of FGFR Alterations and FGFR mRNA Expression in Metastatic Urothelial Cancer Undergoing Checkpoint Inhibitor Therapy

Tully, Karl H. ; Jütte, Hendrik ; Wirtz, Ralph M. ; Jarczyk, Jonas ; Santiago-Walker, Ademi ; Zengerling, Friedemann ; Breyer, Johannes ; Sikic, Danijel ; Kriegmair, Maximilian C. ; von Hardenberg, Jost ; Wullich, Bernd ; Taubert, Helge ; Weyerer, Veronika ; Stoehr, Robert ; Bolenz, Christian ; Burger, Maximilian ; Porubsky, Stefan ; Hartmann, Arndt ; Roghmann, Florian ; Erben, Philipp ; Eckstein, Markus



Abstract

OBJECTIVE To examine the disease-specific survival(DSS) after checkpoint inhibitor(CPI) therapy based on FGFR alterations and FGFR mRNA expression levels in patients with metastatic urothelial cancer(mUCa) within a multi-center cohort. METHODS Within a cohort of 72 patients with mUCa from five academic centers in Germany FGFR alterations, as well as FGFR1-4 mRNA expression levels in tumor samples ...

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