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Molecular pathology of thymomas: implications for diagnosis and therapy

Marx, Alexander ; Belharazem, Djeda ; Lee, De-Hyung ; Popovic, Zoran V. ; Reißfelder, Christoph ; Schalke, Berthold ; Schölch, Sebastian ; Ströbel, Philipp ; Weis, Cleo-Aron ; Yamada, Yosuke



Abstract

Thymomas exhibit a unique genomic landscape, comprising the lowest on average total mutational burden among adult human cancers; a unique point mutation in the GTF2I gene in WHO type A and AB thymomas (and rarely others); almost unique KMT2A-MAML2 translocations in rare WHO type B2 and B3 thymomas; a unique YAP1-MAML2 translocation in almost all metaplastic thymomas; and unique miRNA profiles in ...

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