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Y-chromosome loss is frequent in male renal tumors

Büscheck, Franziska ; Fraune, Christoph ; Garmestani, Seyedehmina ; Simon, Ronald ; Kluth, Martina ; Hube-Magg, Claudia ; Ketterer, Kathrin ; Eichelberg, Christian ; Höflmayer, Doris ; Jacobsen, Frank ; Wittmer, Corinna ; Wilczak, Waldemar ; Sauter, Guido ; Fisch, Margit ; Eichenauer, Till ; Rink, Michael


Background: Loss of the Y-chromosome is a common event in different tumor types but its prevalence and clinical relevance in renal cell tumors is still not understood. Methods: It was the aim of this study to estimate the frequency and clinical relevance of Y-loss in kidney neoplasms. A cohort of 1,252 male renal tumors was analyzed in a tissue microarray format by fluorescence in-situ ...


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