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Matched Family Donor Lymphocyte Infusions as First Cellular Therapy for Patients with Severe Primary T Cell Deficiencies

Hoenig, Manfred ; Roesler, Joachim ; Seidel, Markus G. ; Albert, Michael H. ; Hauck, Fabian ; Maecker-Kolhoff, Britta ; Eiz-Vesper, Britta ; Kleinschmidt, Katharina ; Debatin, Klaus-Michael ; Jacobsen, Eva-Maria ; Furlan, Ingrid ; Suttorp, Meinolf ; Schuetz, Catharina ; Schulz, Ansgar S.



Abstract

Patients with primary immunodeficiencies caused by severe defects in T cell immunity are at risk of acquiring lifethreatening infections. Cellular therapies are necessary to establish normal T cell function and to allow for long-term survival. This is most commonly achieved by hematopoietic stem cell transplantation (HSCT), but the outcome of this procedure is impaired if active infections are ...

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