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A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis

Sinton, Matthew C. ; Meseguer-Ripolles, Jose ; Lucendo-Villarin, Baltasar ; Wernig-Zorc, Sara ; Thomson, John P. ; Carter, Roderick N. ; Lyall, Marcus J. ; Walker, Paul D. ; Thakker, Alpesh ; Meehan, Richard R. ; Lavery, Gareth G. ; Morton, Nicholas M. ; Ludwig, Christian ; Tennant, Daniel A. ; Hay, David C. ; Drake, Amanda J.


Nonalcoholic fatty liver disease (NAFLD) is currently the most prevalent form of liver disease worldwide. This term encompasses a spectrum of pathologies, from benign hepatic steatosis to non-alcoholic steatohepatitis, which have, to date, been challenging to model in the laboratory setting. Here, we present a human pluripotent stem cell (hPSC)-derived model of hepatic steatosis, which overcomes ...


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