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Systematic Review/Meta-Analysis on Efficacy of Allogeneic Hematopoietic Cell Transplantation in Sickle Cell Disease: An International Effort on Behalf of the Pediatric Diseases Working Party of European Society for Blood and Marrow Transplantation and the Sickle Cell Transplantation International Consortium

Iqbal, Madiha ; Reljic, Tea ; Corbacioglu, Selim ; de la Fuente, Josu ; Gluckman, Eliane ; Kumar, Ambuj ; Yassine, Farah ; Ayala, Ernesto ; El-Jawahri, Areej ; Murthy, Hemant ; Almohareb, Fahad ; Hashmi, Shahrukh K. ; Cappelli, Barbara ; Alahmari, Ali ; Scigliuolo, Graziana Maria ; Kassim, Adetola ; Aljurf, Mahmoud ; Kharfan-Dabaja, Mohamed A.



Abstract

Sickle cell disease (SCD) affects more than 300,000 children annually worldwide. Despite improved supportive care, long-term prognosis remains poor. Allogeneic hematopoietic cell transplantation (allo-HCT) is the sole validated curative option, resulting in sustained resolution of the clinical phenotype. The medical literature on allo-HCT for SCD is largely limited to children. Recent studies ...

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