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TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy

Mahler, Christoph ; Schumacher, Adrian-Minh ; Unterrainer, Marcus ; Kaiser, Lena ; Höllbacher, Thomas ; Lindner, Simon ; Havla, Joachim ; Ertl-Wagner, Birgit ; Patzig, Maximilian ; Seelos, Klaus ; Neitzel, Julia ; Mäurer, Matthias ; Krumbholz, Markus ; Metz, Imke ; Brück, Wolfgang ; Stadelmann, Christine ; Merkler, Doron ; Gass, Achim ; Milenkovic, Vladimir ; Bartenstein, Peter ; Albert, Nathalie L ; Kümpfel, Tania ; Kerschensteiner, Martin



Abstract

Progressive multifocal leukoencephalopathy (PML) is a severe infection of the CNS caused by the polyomavirus JC that can occur in multiple sclerosis patients treated with natalizumab. Clinical management of patients with natalizumab-associated PML is challenging not least because current imaging tools for the early detection, longitudinal monitoring and differential diagnosis of PML lesions are ...

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