European Association of Urology (EAU) Prognostic Factor Risk Groups for Non–muscle-invasive Bladder Cancer (NMIBC) Incorporating the WHO 2004/2016 and WHO 1973 Classification Systems for Grade: An Update from the EAU NMIBC Guidelines Panel

Sylvester, Richard J. ; Rodríguez, Oscar ; Hernández, Virginia ; Turturica, Diana ; Bauerová, Lenka ; Bruins, Harman Max ; Bründl, Johannes ; van der Kwast, Theo H. ; Brisuda, Antonin ; Rubio-Briones, José ; Seles, Maximilian ; Hentschel, Anouk E. ; Kusuma, Venkata R.M. ; Huebner, Nicolai ; Cotte, Juliette ; Mertens, Laura S. ; Volanis, Dimitrios ; Cussenot, Olivier ; Subiela Henríquez, Jose D. ; de la Peña, Enrique ; Pisano, Francesca ; Pešl, Michael ; van der Heijden, Antoine G. ; Herdegen, Sonja ; Zlotta, Alexandre R. ; Hacek, Jaromir ; Calatrava, Ana ; Mannweiler, Sebastian ; Bosschieter, Judith ; Ashabere, David ; Haitel, Andrea ; Côté, Jean-François ; El Sheikh, Soha ; Lunelli, Luca ; Algaba, Ferran ; Alemany, Isabel ; Soria, Francesco ; Runneboom, Willemien ; Breyer, Johannes ; Nieuwenhuijzen, Jakko A. ; Llorente, Carlos ; Molinaro, Luca ; Hulsbergen-van de Kaa, Christina A. ; Evert, Matthias ; Kiemeney, Lambertus A.L.M. ; N’Dow, James ; Plass, Karin ; Čapoun, Otakar ; Soukup, Viktor ; Dominguez-Escrig, Jose L. ; Cohen, Daniel ; Palou, Joan ; Gontero, Paolo ; Burger, Maximilian ; Zigeuner, Richard ; Mostafid, Amir Hugh ; Shariat, Shahrokh F. ; Rouprêt, Morgan ; Compérat, Eva M. ; Babjuk, Marko ; van Rhijn, Bas W.G.

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Details

Item type:	Article
Journal or Publication Title:	European Urology
Publisher:	Elsevier
Place of Publication:	AMSTERDAM
Volume:	79
Number of Issue or Book Chapter:	4
Page Range:	pp. 480-488
Date:	2021
Institutions:	Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Urologie
Identification Number:	Value Type 10.1016/j.eururo.2020.12.033 DOI
Keywords:	BACILLUS-CALMETTE-GUERIN; CARCINOMA IN-SITU; PREDICTING RECURRENCE; PROGRESSION; TA; MULTICENTER; SURVIVAL; OUTCOMES; IMPACT; TUMORS; Grade; Guidelines; Non-muscle-invasive bladder cancer; Prognostic factors; Progression; Risk groups; WHO 1973 2004/2016
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	56671

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Abstract

Background: The European Association of Urology (EAU) prognostic factor risk groups for non-muscle-invasive bladder cancer (NMIBC) are used to provide recommendations for patient treatment after transurethral resection of bladder tumor (TURBT). They do not, however, take into account the widely used World Health Organization (WHO) 2004/2016 grading classification and are based on patients treated ...

Abstract

Background: The European Association of Urology (EAU) prognostic factor risk groups for non-muscle-invasive bladder cancer (NMIBC) are used to provide recommendations for patient treatment after transurethral resection of bladder tumor (TURBT). They do not, however, take into account the widely used World Health Organization (WHO) 2004/2016 grading classification and are based on patients treated in the 1980s. Objective: To update EAU prognostic factor risk groups using the WHO 1973 and 2004/2016 grading classifications and identify patients with the lowest and highest probabilities of progression. Design, setting, and participants: Individual patient data for primary NMIBC patients were collected from the institutions of the members of the EAU NMIBC guidelines panel. Intervention: Patients underwent TURBT followed by intravesical instillations at the physician's discretion. Outcome measurements and statistical analysis: Multivariable Cox proportional-hazards regression models were fitted to the primary endpoint, the time to progression to muscle-invasive disease or distant metastases. Patients were divided into four risk groups: low-, intermediate-, high-, and a new, very high-risk group. The probabilities of progression were estimated using Kaplan-Meier curves. Results and limitations: A total of 3401 patients treated with TURBT + intravesical chemotherapy were included. From the multivariable analyses, tumor stage, WHO 1973/2004-2016 grade, concomitant carcinoma in situ, number of tumors, tumor size, and age were used to form four risk groups for which the probability of progression at 5 yr varied from <1% to >40%. Limitations include the retrospective collection of data and the lack of central pathology review. Conclusions: This study provides updated EAU prognostic factor risk groups that can be used to inform patient treatment and follow-up. Incorporating the WHO 2004/2016 and 1973 grading classifications, a new, very high-risk group has been identified for which urologists should be prompt to assess and adapt their therapeutic strategy when necessary. Patient summary: The newly updated European Association of Urology prognostic factor risk groups for non-muscle-invasive bladder cancer provide an improved basis for recommending a patient's treatment and follow-up schedule. (C) 2020 European Association of Urology. Published by Elsevier B.V. All rights reserved.

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