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Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors

Steinbügl, Mona ; Nemes, Karolina ; Johann, Pascal ; Kröncke, Thomas ; Tüchert, Stefanie ; da Costa, Maria Joao Gil ; Ebinger, Martin ; Schüller, Ulrich ; Sehested, Astrid ; Hauser, Peter ; Reinhard, Harald ; Sumerauer, David ; Hettmer, Simone ; Jakob, Marcus ; Hasselblatt, Martin ; Siebert, Reiner ; Witt, Olaf ; Gerss, Joachim ; Kerl, Kornelius ; Frühwald, Michael C.


Background Refined therapy has helped to improve survival rates in rhabdoid tumors (RT). Prognosis for patients with chemoresistant, recurrent, or progressive RT remains dismal. Although decitabine, an epigenetically active agent, has mainly been evaluated in the management of hematologic malignancies in adults, safety in children has also been demonstrated repeatedly. Materials and methods A ...


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