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Preformed T cell alloimmunity and HLA eplet mismatch to guide immunosuppression minimization with tacrolimus monotherapy in kidney transplantation: Results of the CELLIMIN trial

Bestard, Oriol ; Meneghini, Maria ; Crespo, Elena ; Bemelman, Frederike ; Koch, Martina ; Volk, Hans D. ; Viklicky, Ondrej ; Giral, Magali ; Banas, Bernhard ; Ruiz, Juan C. ; Melilli, Edoardo ; Hu, Liu ; van Duivenvoorden, Raphael ; Nashan, Björn ; Thaiss, Friedrich ; Otto, Natalie M. ; Bold, Gantuja ; Stein, Maik ; Sefrin, Anett ; Lachmann, Nils ; Hruba, Petra ; Stranavova, Lucia ; Brouard, Sophie ; Braudeau, Cécile ; Blancho, Gilles ; Banas, Miriam ; Irure, Juan ; Christakoudi, Sophia ; Sanchez-Fueyo, Alberto ; Wood, Kathryn J. ; Reinke, Petra ; Grinyó, Josep M.



Abstract

Personalizing immunosuppression is a major objective in transplantation. Transplant recipients are heterogeneous regarding their immunological memory and primary alloimmune susceptibility. This biomarker-guided trial investigated whether in low immunological-risk kidney transplants without pretransplant DSA and donor-specific T cells assessed by a standardized IFN-gamma ELISPOT, low ...

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