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Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

Winkler, Emma S. ; Gilchuk, Pavlo ; Yu, Jinsheng ; Bailey, Adam L. ; Chen, Rita E. ; Chong, Zhenlu ; Zost, Seth J. ; Jang, Hyesun ; Huang, Ying ; Allen, James D. ; Case, James Brett ; Sutton, Rachel E. ; Carnahan, Robert H. ; Darling, Tamarand L. ; Boon, Adrianus C.M. ; Mack, Matthias ; Head, Richard D. ; Ross, Ted M. ; Crowe, James E. ; Diamond, Michael S.



Zusammenfassung

SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism of action in vivo is incompletely understood. Here, we define correlates of protection of neutralizing human monoclonal antibodies (mAbs) in SARS-CoV-2-infected animals. Whereas Fc effector functions are dispensable when ...

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