Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Brain Sciences | ||||
Verlag: | MDPI | ||||
Ort der Veröffentlichung: | BASEL | ||||
Band: | 11 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 3 | ||||
Seitenbereich: | S. 372 | ||||
Datum: | 2021 | ||||
Institutionen: | Medizin > Lehrstuhl für Neurologie | ||||
Identifikationsnummer: |
| ||||
Stichwörter / Keywords: | AMYOTROPHIC-LATERAL-SCLEROSIS; ASSESSMENT QUESTIONNAIRE ALSAQ-40; FUNCTIONAL RATING-SCALE; NONINVASIVE VENTILATION; SURVIVAL; DEPRESSION; VERSION; RELIABILITY; VALIDATION; VALIDITY; Amyotrophic Lateral Sclerosis (ALS); Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5); ALS treatment; "bulbar-onset" ALS (bALS); "limb-onset" ALS (lALS); EuroQol Five Dimension Five Level Scale (EQ-5D-5L); health-related quality of life (HRQoL); quality of life (QoL); symptom-specific treatment; assistive devices | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 56734 |
Zusammenfassung
Improving quality of life (QoL) is central to amyotrophic lateral sclerosis (ALS) treatment. This Germany-wide, multicenter cross-sectional study analyses the impact of different symptom-specific treatments and ALS variants on QoL. Health-related QoL (HRQoL) in 325 ALS patients was assessed using the Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) and EuroQol Five Dimension ...
Zusammenfassung
Improving quality of life (QoL) is central to amyotrophic lateral sclerosis (ALS) treatment. This Germany-wide, multicenter cross-sectional study analyses the impact of different symptom-specific treatments and ALS variants on QoL. Health-related QoL (HRQoL) in 325 ALS patients was assessed using the Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) and EuroQol Five Dimension Five Level Scale (EQ-5D-5L), together with disease severity (captured by the revised ALS Functional Rating Scale (ALSFRS-R)) and the current care and therapies used by our cohort. At inclusion, the mean ALSAQ-5 total score was 56.93 (max. 100, best = 0) with a better QoL associated with a less severe disease status (beta = -1.96 per increase of one point in the ALSFRS-R score, p < 0.001). "Limb-onset" ALS (lALS) was associated with a better QoL than "bulbar-onset" ALS (bALS) (mean ALSAQ-5 total score 55.46 versus 60.99, p = 0.040). Moreover, with the ALSFRS-R as a covariate, using a mobility aid (beta = -7.60, p = 0.001), being tracheostomized (beta = -14.80, p = 0.004) and using non-invasive ventilation (beta = -5.71, p = 0.030) were associated with an improved QoL, compared to those at the same disease stage who did not use these aids. In contrast, antidepressant intake (beta = 5.95, p = 0.007), and increasing age (beta = 0.18, p = 0.023) were predictors of worse QoL. Our results showed that the ALSAQ-5 was better-suited for ALS patients than the EQ-5D-5L. Further, the early and symptom-specific clinical management and supply of assistive devices can significantly improve the individual HRQoL of ALS patients. Appropriate QoL questionnaires are needed to monitor the impact of treatment to provide the best possible and individualized care.
Metadaten zuletzt geändert: 29 Feb 2024 12:37