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Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study

Mayén, Ana‐Lucia ; Aglago, Elom K. ; Knaze, Viktoria ; Cordova, Reynalda ; Schalkwijk, Casper G. ; Wagner, Karl‐Heinz ; Aleksandrova, Krasimira ; Fedirko, Veronika ; Keski‐Rahkonen, Pekka ; Leitzmann, Michael F. ; Katzke, Verena ; Srour, Bernard ; Schulze, Matthias B. ; Masala, Giovanna ; Krogh, Vittorio ; Panico, Salvatore ; Tumino, Rosario ; Bueno‐de‐Mesquita, Bas ; Brustad, Magritt ; Agudo, Antonio ; Chirlaque López, María Dolores ; Amiano, Pilar ; Ohlsson, Bodil ; Ramne, Stina ; Aune, Dagfinn ; Weiderpass, Elisabete ; Jenab, Mazda ; Freisling, Heinz



Abstract

Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer ...

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