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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIb. The 2020 Preemptive Therapy Working Group Report

Pidala, Joseph ; Kitko, Carrie ; Lee, Stephanie J. ; Carpenter, Paul ; Cuvelier, Geoffrey D.E. ; Holtan, Shernan ; Flowers, Mary E. ; Cutler, Corey ; Jagasia, Madan ; Gooley, Ted ; Palmer, Joycelynne ; Randolph, Tim ; Levine, John E. ; Ayuk, Francis ; Dignan, Fiona ; Schoemans, Helene ; Tkaczyk, Eric ; Farhadfar, Nosha ; Lawitschka, Anita ; Schultz, Kirk R. ; Martin, Paul J. ; Sarantopoulos, Stefanie ; Inamoto, Yoshihiro ; Socie, Gerard ; Wolff, Daniel ; Blazar, Bruce ; Greinix, Hildegard ; Paczesny, Sophie ; Pavletic, Steven ; Hill, Geoffrey



Zusammenfassung

Chronic graft-versus-host disease (GVHD) commonly occurs after allogeneic hematopoietic cell transplantation (HCT) despite standard prophylactic immune suppression. Intensified universal prophylaxis approaches are effective but risk possible overtreatment and may interfere with the graft-versus-malignancy immune response. Here we summarize conceptual and practical considerations regarding ...

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