; Pignolet, Béatrice ; Görlich, Dennis ; Andlauer, Till F. M.
; Schulte-Mecklenbeck, Andreas
; Gonzalez-Escamilla, Gabriel ; Bucciarelli, Florence ; Gennero, Isabelle
; Breuer, Johanna ; Antony, Gisela ; Schneider-Hohendorf, Tilman
; Mykicki, Nadine ; Bayas, Antonios ; Then Bergh, Florian ; Bittner, Stefan ; Hartung, Hans-Peter ; Friese, Manuel A. ; Linker, Ralf A. ; Luessi, Felix ; Lehmann-Horn, Klaus ; Mühlau, Mark ; Paul, Friedemann ; Stangel, Martin ; Tackenberg, Björn ; Tumani, Hayrettin ; Warnke, Clemens ; Weber, Frank ; Wildemann, Brigitte ; Zettl, Uwe K. ; Ziemann, Ulf ; Müller-Myhsok, Bertram ; Kümpfel, Tania ; Klotz, Luisa ; Meuth, Sven G. ; Zipp, Frauke
; Hemmer, Bernhard
; Hohlfeld, Reinhard ; Brassat, David ; Gold, Ralf ; Gross, Catharina C.
; Lukas, Carsten
; Groppa, Sergiu ; Loser, Karin ; Wiendl, Heinz ; Schwab, Nicholas
; Bayas, Antonios ; Rothacher, Susanne ; Starke, Stephanie ; Paul, Friedemann ; Bellmann-Strobl, Judith ; Behrens, Janina ; Dörr, Jan-Markus ; Gieß, Rene ; Kuchling, Joseph ; Rasche, Ludwig ; Gold, Ralf ; Chan, Andrew ; Ellrichmann, Gisa ; Fisse, Anna Lena ; Gahlen, Anna ; Grüter, Thomas ; Haghikia, Aiden ; Hoepner, Robert ; Koc, Ümmügülsün ; Lukas, Carsten ; Motte, Jeremias ; Pitarokoili, Kalliopi ; Salmen, Anke ; Schneider, Ruth ; Schöllhammer, Joanna ; Schroeder, Christoph ; Ambrosius, Björn ; Demir, Seray ; Warnke, Clemens ; Dehmel, Thomas ; Ingenhoven, Kathleen ; Linker, Ralf ; Lee, De-Hyung ; Lämmer, Alexandra ; Sauer, Eva ; Heesen, Christoph ; Stellmann, Jan-Patrick ; Stangel, Martin ; Boenig, Lena ; Gingele, Stefan ; Hümmert, Martin ; Schwenkenbecher, Philipp ; Skripuletz, Thomas ; Suehs, Wolfram ; Wildemann, Brigitte ; Korporal-Kuhnke, Mirjam ; Oßwald, Hanna ; Schwarz, Alexander ; Viehöver, Andrea ; Limmroth, Volker ; Gerbershagen, Kathrin ; Bergh, Florian Then ; Ettrich, Barbara ; Gray, Steffi ; Haars, Sarah ; Orthgieß, Johannes ; Schwanitz, Nicole ; Stoppe, Muriel ; Unterlauft, Astrid ; Paryjas, Sandra ; Bittner, Stefan ; Fleischer, Vinzenz ; Groppa, Sergiu ; Lüssi, Felix ; Piepgras, Johannes ; Uphaus, Timo ; Tackenberg, Björn ; Pütz, Michael ; Eienbröker, Christian ; Seipelt, Maria ; Hohlfeld, Reinhard ; Kümpfel, Tania ; Havla, Joachim ; Meinl, Ingrid ; Pellkofer, Hannah ; Schuh, Elisabeth ; Hemmer, Bernhard ; Aly, Lilian ; Berthele, Achim ; Pongratz, Viola ; Brinkhoff, Kirsten ; Buck, Dorothea ; Gasperi, Christiane ; Hermisson, Mirjam ; Hoshi, Muna-Miriam ; Kaminski, Miriam ; Klein, Ana ; Knier, Benjamin ; Kowarik, Markus ; Kronsbein, Helena ; Horn, Klaus Lehmann ; Mitsdörffer, Meike ; Pernpeintner, Verena ; Rothhammer, Veit ; Schweikert, Andrea ; Selter, Rebecca ; Mühlau, Mark ; Zimmer, Claus ; Kirschke, Jan ; Weber, Frank ; Staufer, Heike ; Knop, Matthias ; Nischwitz, Sandra ; Sämann, Philipp ; Wiendl, Heinz ; Meuth, Sven ; Klotz, Luisa ; Meyer zu Hörste, Gerd ; Krämer, Julia ; Schünemann, Lena ; Gross, Catharina ; Pfeuffer, Steffen ; Ruck, Tobias ; Belgriri, Selma ; Buchheister, Alexander ; Bünger, Nora ; Göbel, Kerstin ; Kirstein, Lucienne ; Melzer, Nico ; Simon, Ole ; Echterhoff, Antje ; Zettl, Uwe ; Winkelmann, Alexander ; Ziemann, Ulf ; Abdelhak, Ahmed ; Kowarik, Markus ; Krumbholz, Markus ; Paech, Margarete ; Ruschil, Christoph ; Stefanou, Maria-Ioanna ; Tünnerhoff, Johannes ; Zeltner, Lena ; Sheikh, Hajera ; Tumani, Hayrettin ; Fangerau, Tanja ; Lauda, Florian ; Rau, Daniela ; Taranu, Daniela ; Huss, André ; Brassat, David ; Pignolet, Béatrice ; Bucciarelli, Florence ; Scandella, Lise ; Lebrun-Frenay, Christine ; Debouverie, Marc ; Pittion-Vouyovitch, Sophie ; Brochet, Bruno ; Ruet, Aurelie ; Defer, Gilles ; Derache, Nathalie ; de Sèze, Jérôme ; Laplaud, David ; Wiertlewski, Sandrine ; Casez, Oliver ; Clavelou, Pierre ; Labauge, Pierre ; Pelletier, Jean ; Rico, Audrey ; Vukusic, Sandra ; Outteryck, Olivier ; Jean-Claude, ; Ouallet, Jean-Christophe ; Hautecoeur, Patrick ; Tourbah, Ayman ; Castelnovo, Giovanni ; Berger, Eric ; Zéphir, Hélène ; Cabre, Philippe ; Camu, William ; Thouvenot, Eric ; Moreau, Thibault ; Fromont, Agnès ; Papeix, Caroline ; Lubetzki, Catherine ; Vermersch, Patrick ; Cohen, Mikael ; Rumbach, Lucien | Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Proceedings of the National Academy of Sciences | ||||
| Verlag: | NATL ACAD SCIENCES | ||||
| Ort der Veröffentlichung: | WASHINGTON | ||||
| Band: | 118 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
| Datum: | 2021 | ||||
| Institutionen: | Medizin > Lehrstuhl für Neurologie | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | VITAMIN-D; INTERFERON-BETA; I INTERFERON; 25-HYDROXYVITAMIN D; DISEASE-ACTIVITY; UV-RADIATION; SUN EXPOSURE; RECEPTOR; RISK; HORMONE; sunlight; multiple sclerosis; vitamin D; latitude; melanocortin 1 receptor | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 56776 |
Zusammenfassung
Multiple sclerosis (MS) disease risk is associated with reduced sunexposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n(NationMS) = 946, n(BIONAT) = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum ...

Zusammenfassung
Multiple sclerosis (MS) disease risk is associated with reduced sunexposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n(NationMS) = 946, n(BIONAT) = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-beta-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests benefidal effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.
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