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Dokumentenart: | Artikel | ||||
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Titel eines Journals oder einer Zeitschrift: | Proceedings of the National Academy of Sciences | ||||
Verlag: | NATL ACAD SCIENCES | ||||
Ort der Veröffentlichung: | WASHINGTON | ||||
Band: | 118 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 1 | ||||
Datum: | 2021 | ||||
Institutionen: | Medizin > Lehrstuhl für Neurologie | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | VITAMIN-D; INTERFERON-BETA; I INTERFERON; 25-HYDROXYVITAMIN D; DISEASE-ACTIVITY; UV-RADIATION; SUN EXPOSURE; RECEPTOR; RISK; HORMONE; sunlight; multiple sclerosis; vitamin D; latitude; melanocortin 1 receptor | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 56776 |
Zusammenfassung
Multiple sclerosis (MS) disease risk is associated with reduced sunexposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n(NationMS) = 946, n(BIONAT) = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum ...
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Zusammenfassung
Multiple sclerosis (MS) disease risk is associated with reduced sunexposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n(NationMS) = 946, n(BIONAT) = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-beta-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests benefidal effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS.
Metadaten zuletzt geändert: 29 Feb 2024 12:37