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Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality

Schunk, Stefan J. ; Kleber, Marcus E. ; März, Winfried ; Pang, Shichao ; Zewinger, Stephen ; Triem, Sarah ; Ege, Philipp ; Reichert, Matthias C. ; Krawczyk, Marcin ; Weber, Susanne N. ; Jaumann, Isabella ; Schmit, David ; Sarakpi, Tamim ; Wagenpfeil, Stefan ; Kramann, Rafael ; Boerwinkle, Eric ; Ballantyne, Christie M. ; Grove, Megan L. ; Tragante, Vinicius ; Pilbrow, Anna P. ; Richards, A. Mark ; Cameron, Vicky A. ; Doughty, Robert N. ; Dubé, Marie-Pierre ; Tardif, Jean-Claude ; Feroz-Zada, Yassamin ; Sun, Maxine ; Liu, Chang ; Ko, Yi-An ; Quyyumi, Arshed A. ; Hartiala, Jaana A. ; Tang, W. H. Wilson ; Hazen, Stanley L. ; Allayee, Hooman ; McDonough, Caitrin W. ; Gong, Yan ; Cooper-DeHoff, Rhonda M. ; Johnson, Julie A. ; Scholz, Markus ; Teren, Andrej ; Burkhardt, Ralph ; Martinsson, Andreas ; Smith, J. Gustav ; Wallentin, Lars ; James, Stefan K. ; Eriksson, Niclas ; White, Harvey ; Held, Claes ; Waterworth, Dawn ; Trompet, Stella ; Jukema, J. Wouter ; Ford, Ian ; Stott, David J. ; Sattar, Naveed ; Cresci, Sharon ; Spertus, John A. ; Campbell, Hannah ; Tierling, Sascha ; Walter, Jörn ; Ampofo, Emmanuel ; Niemeyer, Barbara A. ; Lipp, Peter ; Schunkert, Heribert ; Böhm, Michael ; Koenig, Wolfgang ; Fliser, Danilo ; Laufs, Ulrich ; Speer, Thimoteus



Abstract

Aims Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1 beta can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation ...

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