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Novel pathomechanism for spontaneous bacterial peritonitis: disruption of cell junctions by cellular and bacterial proteases

Haderer, Marika ; Neubert, Philip ; Rinner, Eva ; Scholtis, Annika ; Broncy, Lucile ; Gschwendtner, Heidi ; Kandulski, Arne ; Pavel, Vlad ; Mehrl, Alexander ; Brochhausen, Christoph ; Schlosser, Sophie ; Gülow, Karsten ; Kunst, Claudia ; Müller, Martina



Zusammenfassung

Objective Spontaneous bacterial peritonitis (SBP) is a life-threatening complication of liver cirrhosis with a 1-year mortality of 66%. Bacterial translocation (BT) from the intestine to the mesenteric lymph nodes is crucial for the pathogenesis of SBP. Design Since BT presupposes a leaky intestinal epithelium, the integrity of mucus and epithelial cell junctions (E-cadherin and occludin) was ...

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