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Association study of candidate DNA-repair gene variants and acute graft versus host disease in pediatric patients receiving allogeneic hematopoietic stem-cell transplantation

Uppugunduri, C. R. S. ; Huezo-Diaz Curtis, P. ; Nava, T. ; Rezgui, M. A. ; Mlakar, V. ; Mlakar, S. Jurkovic ; Waespe, N. ; Théoret, Y. ; Gumy-Pause, F. ; Bernard, F. ; Chalandon, Y. ; Boelens, J. J. ; Bredius, R. G. M. ; Dalle, J. H. ; Nath, C. ; Corbacioglu, S. ; Peters, C. ; Bader, P. ; Shaw, P. ; Bittencourt, H. ; Krajinovic, M. ; Ansari, M.



Zusammenfassung

Acute Graft versus Host Disease (aGvHD) grades 2-4 occurs in 15-60% of pediatric patients undergoing allogeneic haematopoietic stem-cell transplantation (allo-HSCT). The collateral damage to normal tissue by conditioning regimens administered prior to allo-HSCT serve as an initial trigger for aGvHD. DNA-repair mechanisms may play an important role in mitigating this initial damage, and so the ...

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