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Animal experimental investigation on the efficacy of antibiotic therapy with linezolid, vancomycin, cotrimoxazole, and rifampin in treatment of periprosthetic knee joint infections by MRSA

Goetz, Julia ; Keyssner, Verena ; Hanses, Frank ; Greimel, Felix ; Leiß, Franziska ; Schwarz, Timo ; Springorum, Hans-Robert ; Grifka, Joachim ; Schaumburger, Jens


Aims Periprosthetic joint infections (PJIs) are rare, but represent a great burden for the patient. In addition, the incidence of methicillin-resistant Staphylococcus aureus (MRSA) is increasing. The aim of this rat experiment was therefore to compare the antibiotics commonly used in the treatment of PJIs caused by MRSA. Methods For this purpose, sterilized steel implants were implanted into the ...


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