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Pharmacologic Targeting of MMP2/9 Decreases Peritoneal Metastasis Formation of Colorectal Cancer in a Human Ex Vivo Peritoneum Culture Model

Koch, Jana ; Mönch, Dina ; Maaß, Annika ; Mangold, Alina ; Gužvić, Miodrag ; Mürdter, Thomas ; Leibold, Tobias ; Dahlke, Marc-H. ; Renner, Philipp


Simple Summary We investigated the effects of matrix metalloproteinases (MMPs) on the peritoneal attachment of colorectal cancer cells in patient samples and in a human ex vivo peritoneum model. MMP2/9 overexpression and enhanced fibronectin cleavage occurred during peritoneal colonisation, which could be inhibited by specific MMP inhibition, thereby reducing cancer cell attachment. Background: ...


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