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Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function

Cheng, Hung-Wei ; Mörbe, Urs ; Lütge, Mechthild ; Engetschwiler, Céline ; Onder, Lucas ; Novkovic, Mario ; Gil-Cruz, Cristina ; Perez-Shibayama, Christian ; Hehlgans, Thomas ; Scandella, Elke ; Ludewig, Burkhard


Innate lymphoid cells (ILCs) govern immune cell homeostasis in the intestine and protect the host against microbial pathogens. Various cell-intrinsic pathways have been identified that determine ILC development and differentiation. However, the cellular components that regulate ILC sustenance and function in the intestinal lamina propria are less known. Using single-cell transcriptomic analysis ...


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