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The value of time-dependent risk predictions in a screening context - a comprehensive simulation analysis validated on German cancer registry data

Voelkel, Vinzenz ; Draeger, Teresa ; van Mossel, Sietse ; Siesling, Sabine ; Koffijberg, Hendrik


Background Risk-prediction tools allow classifying individuals into risk groups based on risk thresholds. Such risk categorization is often used to inform screening schemes by offering screening only to individuals at increased risk of harmful events. Adding information concerning an individual's risk development over time would allow assessing not just who to screen but also when to screen. This ...


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