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The S-palmitoylome and DHHC-PAT interactome of Drosophila melanogaster S2R+ cells indicate a high degree of conservation to mammalian palmitoylomes

Giansanti, Maria Grazia ; Porcellato, Elena ; González-Sánchez, Juan Carlos ; Ahlmann-Eltze, Constantin ; Elsakka, Mahmoud Ali ; Shapira, Itamar ; Fritsch, Jürgen ; Navarro, Juan Antonio ; Anders, Simon ; Russell, Robert B. ; Wieland, Felix T. ; Metzendorf, Christoph


Protein S-palmitoylation, the addition of a long-chain fatty acid to target proteins, is among the most frequent reversible protein modifications in Metazoa, affecting subcellular protein localization, trafficking and protein-protein interactions. S-palmitoylated proteins are abundant in the neuronal system and are associated with neuronal diseases and cancer. Despite the importance of this ...


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