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Severe Dysbiosis and Specific Haemophilus and Neisseria Signatures as Hallmarks of the Oropharyngeal Microbiome in Critically Ill Coronavirus Disease 2019 (COVID-19) Patients

de Castilhos, Juliana ; Zamir, Eli ; Hippchen, Theresa ; Rohrbach, Roman ; Schmidt, Sabine ; Hengler, Silvana ; Schumacher, Hanna ; Neubauer, Melanie ; Kunz, Sabrina ; Müller-Esch, Tonia ; Hiergeist, Andreas ; Gessner, André ; Khalid, Dina ; Gaiser, Rogier ; Cullin, Nyssa ; Papagiannarou, Stamatia M ; Beuthien-Baumann, Bettina ; Krämer, Alwin ; Bartenschlager, Ralf ; Jäger, Dirk ; Müller, Michael ; Herth, Felix ; Duerschmied, Daniel ; Schneider, Jochen ; Schmid, Roland M ; Eberhardt, Johann F ; Khodamoradi, Yascha ; Vehreschild, Maria J G T ; Teufel, Andreas ; Ebert, Matthias P ; Hau, Peter ; Salzberger, Bernd ; Schnitzler, Paul ; Poeck, Hendrik ; Elinav, Eran ; Merle, Uta ; Stein-Thoeringer, Christoph K



Abstract

Background At the entry site of respiratory virus infections, the oropharyngeal microbiome has been proposed as a major hub integrating viral and host immune signals. Early studies suggested that infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are associated with changes of the upper and lower airway microbiome, and that specific microbial signatures may predict ...

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