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Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration

Tabel, Mona ; Wolf, Anne ; Szczepan, Manon ; Xu, Heping ; Jägle, Herbert ; Moehle, Christoph ; Chen, Mei ; Langmann, Thomas


Background Dysfunctional humoral and cellular innate immunity are key components in the development and progression of age-related macular degeneration (AMD). Specifically, chronically activated microglia and their disturbed regulatory system contribute to retinal degeneration. Galectin-3, a beta-galactose binding protein, is a potent driver of macrophage and microglia activation and has been ...


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