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The Coxiella burnetii T4SS effector protein AnkG hijacks the 7SK small nuclear ribonucleoprotein complex for reprogramming host cell transcription

Zamboni, Dario S. ; Cordsmeier, Arne ; Rinkel, Sven ; Jeninga, Myriam ; Schulze-Luehrmann, Jan ; Ölke, Martha ; Schmid, Benedikt ; Hasler, Daniele ; Meister, Gunter ; Häcker, Georg ; Petter, Michaela ; Beare, Paul A. ; Lührmann, Anja


Inhibition of host cell apoptosis is crucial for survival and replication of several intracellular bacterial pathogens. To interfere with apoptotic pathways, some pathogens use specialized secretion systems to inject bacterial effector proteins into the host cell cytosol. One of these pathogens is the obligate intracellular bacterium Coxiella burnetii, the etiological agent of the zoonotic ...


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