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The Vibrio vulnificus stressosome is an oxygen-sensor involved in regulating iron metabolism

Heinz, Veronika ; Jäckel, Wenke ; Kaltwasser, Susann ; Cutugno, Laura ; Bedrunka, Patricia ; Graf, Anica ; Reder, Alexander ; Michalik, Stephan ; Dhople, Vishnu M. ; Madej, M. Gregor ; Conway, Maria ; Lechner, Marcus ; Riedel, Katharina ; Bange, Gert ; Boyd, Aoife ; Völker, Uwe ; Lewis, Richard J. ; Marles-Wright, Jon ; Ziegler, Christine ; Pané-Farré, Jan



Abstract

A cryo-electron microscopy reconstruction of a stressosome complex from a Gram-negative bacterium, Vibrio vulnificus, reveals variations in subunit composition and symmetry, which could serve to adjust the activation threshold in the response to low levels of oxygen and starvation. Stressosomes are stress-sensing protein complexes widely conserved among bacteria. Although a role in the regulation ...

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