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Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota

Moitinho-Silva, Lucas ; Degenhardt, Frauke ; Rodriguez, Elke ; Emmert, Hila ; Juzenas, Simonas ; Möbus, Lena ; Uellendahl-Werth, Florian ; Sander, Nicole ; Baurecht, Hansjörg ; Tittmann, Lukas ; Lieb, Wolfgang ; Gieger, Christian ; Peters, Annette ; Ellinghaus, David ; Bang, Corinna ; Franke, Andre ; Weidinger, Stephan ; Rühlemann, Malte Christoph



Abstract

Despite the increasing knowledge about factors shaping the human microbiome, the host genetic factors that modulate the skin-microbiome interactions are still largely understudied. This contrasts with recent efforts to characterize host genes that influence the gut microbiota. Here, we investigated the effect of genetics on skin microbiota across three different skin microenvironments through ...

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