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The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite Plasmodium Falciparum Cooperates With PfBDP1 in the Silencing of Variant Surface Antigen Expression

Quinn, Jennifer E. ; Jeninga, Myriam D. ; Limm, Katharina ; Pareek, Kapil ; Meißgeier, Tina ; Bachmann, Anna ; Duffy, Michael F. ; Petter, Michaela



Abstract

Epigenetic regulation is a critical mechanism in controlling virulence, differentiation, and survival of the human malaria parasite Plasmodium (P.) falciparum. Bromodomain proteins contribute to this process by binding to acetylated lysine residues of histones and thereby targeting the gene regulatory machinery to gene promoters. A protein complex containing the P. falciparum bromodomain proteins ...

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