Zeyen, Thomas ; Potthoff, Anna-Laura ; Nemeth, Robert ; Heiland, Dieter H. ; Burger, Michael C. ; Steinbach, Joachim P. ; Hau, Peter ; Tabatabai, Ghazaleh ; Glas, Martin ; Schlegel, Uwe ; Grauer, Oliver ; Krex, Dietmar ; Schnell, Oliver ; Goldbrunner, Roland ; Sabel, Michael 
; Thon, Niklas ; Delev, Daniel ; Clusmann, Hans ; Seidel, Clemens ; Güresir, Erdem ; Schmid, Matthias ; Schuss, Patrick ; Giordano, Frank A. ; Radbruch, Alexander ; Becker, Albert ; Weller, Johannes ; Schaub, Christina ; Vatter, Hartmut ; Schilling, Judith ; Winkler, Frank ; Herrlinger, Ulrich ; Schneider, Matthias
; Thon, Niklas ; Delev, Daniel ; Clusmann, Hans ; Seidel, Clemens ; Güresir, Erdem ; Schmid, Matthias ; Schuss, Patrick ; Giordano, Frank A. ; Radbruch, Alexander ; Becker, Albert ; Weller, Johannes ; Schaub, Christina ; Vatter, Hartmut ; Schilling, Judith ; Winkler, Frank ; Herrlinger, Ulrich ; Schneider, Matthias 
Abstract
Background: Glioblastoma is the most frequent and malignant primary brain tumor. Even in the subgroup with O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and favorable response to first-line therapy, survival after relapse is short (12 months). Standard therapy for recurrent MGMT-methylated glioblastoma is not standardized and may consist of re-resection, re-irradiation, and ...
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