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A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis

Lluch, Aina ; Veiga, Sonia R. ; Latorre, Jèssica ; Moreno-Navarrete, José M. ; Bonifaci, Núria ; Van Dien, Nguyen ; Zhou, You ; Höring, Marcus ; Liebisch, Gerhard ; Olkkonen, Vesa M. ; Llobet-Navas, David ; Thomas, George ; Rodríguez-Barrueco, Ruth ; Fernández-Real, José M. ; Kozma, Sara C. ; Ortega, Francisco J.



Zusammenfassung

The ribosomal protein S6 kinase 1 (S6K1) is a relevant effector downstream of the mammalian target of rapamycin complex 1 (mTORC1), best known for its role in the control of lipid homeostasis. Consistent with this, mice lacking the S6k1 gene have a defect in their ability to induce the commitment of fat precursor cells to the adipogenic lineage, which contributes to a significant reduction of fat ...

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