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Impact of Partial Volume Correction on [18F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome

Schuster, Sebastian ; Beyer, Leonie ; Palleis, Carla ; Harris, Stefanie ; Schmitt, Julia ; Weidinger, Endy ; Prix, Catharina ; Bötzel, Kai ; Danek, Adrian ; Rauchmann, Boris-Stephan ; Stöcklein, Sophia ; Lindner, Simon ; Unterrainer, Marcus ; Albert, Nathalie L. ; Mittlmeier, Lena M. ; Wetzel, Christian ; Rupprecht, Rainer ; Rominger, Axel ; Bartenstein, Peter ; Perneczky, Robert ; Levin, Johannes ; Höglinger, Günter U. ; Brendel, Matthias ; Dekorsy, Franziska J.



Abstract

Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared to a control cohort imaged with the 18-kDa translocator protein (TSPO) positron emission tomography ...

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