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Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis

Witzel, Simon ; Maier, André ; Steinbach, Robert ; Grosskreutz, Julian ; Koch, Jan C. ; Sarikidi, Anastasia ; Petri, Susanne ; Günther, René ; Wolf, Joachim ; Hermann, Andreas ; Prudlo, Johannes ; Cordts, Isabell ; Lingor, Paul ; Löscher, Wolfgang N. ; Kohl, Zacharias ; Hagenacker, Tim ; Ruckes, Christian ; Koch, Birgit ; Spittel, Susanne ; Günther, Kornelia ; Michels, Sebastian ; Dorst, Johannes ; Meyer, Thomas ; Ludolph, Albert C.



Abstract

IMPORTANCE Intravenous edaravone is approved as a disease-modifying drug for patients with amyotrophic lateral sclerosis (ALS), but evidence for efficacy is limited to short-term beneficial effects shown in the MCI186-ALS19 study in a subpopulation in which efficacy was expected. OBJECTIVE To evaluate the long-term safety and effectiveness of intravenous edaravone therapy for patients with ALS in ...

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