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Lipidomic profiling of human serum enables detection of pancreatic cancer

Wolrab, Denise ; Jirásko, Robert ; Cífková, Eva ; Höring, Marcus ; Mei, Ding ; Chocholoušková, Michaela ; Peterka, Ondřej ; Idkowiak, Jakub ; Hrnčiarová, Tereza ; Kuchař, Ladislav ; Ahrends, Robert ; Brumarová, Radana ; Friedecký, David ; Vivo-Truyols, Gabriel ; Škrha, Pavel ; Škrha, Jan ; Kučera, Radek ; Melichar, Bohuslav ; Liebisch, Gerhard ; Burkhardt, Ralph ; Wenk, Markus R. ; Cazenave-Gassiot, Amaury ; Karásek, Petr ; Novotný, Ivo ; Greplová, Kristína ; Hrstka, Roman ; Holčapek, Michal



Abstract

Pancreatic cancer has the worst prognosis among all cancers. Cancer screening of body fluids may improve the survival time prognosis of patients, who are often diagnosed too late at an incurable stage. Several studies report the dysregulation of lipid metabolism in tumor cells, suggesting that changes in the blood lipidome may accompany tumor growth. Here we show that the comprehensive mass ...

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