Dokumentenart: | Artikel | ||||
---|---|---|---|---|---|
Titel eines Journals oder einer Zeitschrift: | Investigative Opthalmology & Visual Science | ||||
Verlag: | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | ||||
Ort der Veröffentlichung: | ROCKVILLE | ||||
Band: | 63 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 2 | ||||
Seitenbereich: | S. 12 | ||||
Datum: | 2022 | ||||
Institutionen: | Biologie und Vorklinische Medizin > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie | ||||
Identifikationsnummer: |
| ||||
Stichwörter / Keywords: | OPEN-ANGLE GLAUCOMA; TRABECULAR MESHWORK CELLS; OPTIC-NERVE DAMAGE; INTRAOCULAR-PRESSURE; EXTRACELLULAR-MATRIX; HYDROGEN-SULFIDE; RESCUES GLAUCOMA; HUMAN EYES; SYMPATHETIC NEUROTRANSMISSION; NONINVASIVE DETERMINATION; mouse model; conventional outflow; glaucoma; intraocular pressure; ocular hypertension; outflow facility | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 57744 |
Zusammenfassung
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this ...
Zusammenfassung
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
Metadaten zuletzt geändert: 29 Feb 2024 13:02