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Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

McDowell, Colleen M. ; Kizhatil, Krishnakumar ; Elliott, Michael H. ; Overby, Darryl R. ; van Batenburg-Sherwood, Joseph ; Millar, J. Cameron ; Kuehn, Markus H. ; Zode, Gulab ; Acott, Ted S. ; Anderson, Michael G. ; Bhattacharya, Sanjoy K. ; Bertrand, Jacques A. ; Borras, Terete ; Bovenkamp, Diane E. ; Cheng, Lin ; Danias, John ; De Ieso, Michael Lucio ; Du, Yiqin ; Faralli, Jennifer A. ; Fuchshofer, Rudolf ; Ganapathy, Preethi S. ; Gong, Haiyan ; Herberg, Samuel ; Hernandez, Humberto ; Humphries, Peter ; John, Simon W. M. ; Kaufman, Paul L. ; Keller, Kate E. ; Kelley, Mary J. ; Kelly, Ruth A. ; Krizaj, David ; Kumar, Ajay ; Leonard, Brian C. ; Lieberman, Raquel L. ; Liton, Paloma ; Liu, Yutao ; Liu, Katy C. ; Lopez, Navita N. ; Mao, Weiming ; Mavlyutov, Timur ; McDonnell, Fiona ; McLellan, Gillian J. ; Mzyk, Philip ; Nartey, Andrews ; Pasquale, Louis R. ; Patel, Gaurang C. ; Pattabiraman, Padmanabhan P. ; Peters, Donna M. ; Raghunathan, Vijaykrishna ; Rao, Ponugoti Vasantha ; Rayana, Naga ; Raychaudhuri, Urmimala ; Reina-Torres, Ester ; Ren, Ruiyi ; Rhee, Douglas ; Chowdhury, Uttio Roy ; Samples, John R. ; Samples, E. Griffen ; Sharif, Najam ; Schuman, Joel S. ; Sheffield, Val C. ; Stevenson, Cooper H. ; Soundararajan, Avinash ; Subramanian, Preeti ; Sugali, Chenna Kesavulu ; Sun, Yang ; Toris, Carol B. ; Torrejon, Karen Y. ; Vahabikashi, Amir ; Vranka, Janice A. ; Wang, Ting ; Willoughby, Colin E. ; Xin, Chen ; Yun, Hongmin ; Zhang, Hao F. ; Fautsch, Michael P. ; Tamm, Ernst R. ; Clark, Abbot F. ; Ethier, C. Ross ; Stamer, W. Daniel



Abstract

Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this ...

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