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Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms

Schmidt, Andreas W. ; Kühnapfel, Andreas ; Kirsten, Holger ; Grallert, Harald ; Hellerbrand, Claus ; Kiefer, Falk ; Mann, Karl ; Mueller, Sebastian ; Nöthen, Markus M. ; Peters, Annette ; Ridinger, Monika ; Frank, Josef ; Rietschel, Marcella ; Soranzo, Nicole ; Soyka, Michael ; Wodarz, Norbert ; Malerba, Giovanni ; Gambaro, Giovanni ; Gieger, Christian ; Scholz, Markus ; Krug, Sebastian ; Michl, Patrick ; Ewers, Maren ; Witt, Heiko ; Laumen, Helmut ; Rosendahl, Jonas



Abstract

Background: Previous genome-wide association studies (GWAS) identified genome-wide significant risk loci in chronic pancreatitis and investigated underlying disease causing mechanisms by simple overlaps with expression quantitative trait loci (eQTLs), a procedure which may often result in false positive conclusions. Methods: We conducted a GWAS in 584 non-alcoholic chronic pancreatitis (NACP) ...

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