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Metabolic Profiling of Thymic Epithelial Tumors Hints to a Strong Warburg Effect, Glutaminolysis and Precarious Redox Homeostasis as Potential Therapeutic Targets

Alwahsh, Mohammad ; Knitsch, Robert ; Marchan, Rosemarie ; Lambert, Jörg ; Hoerner, Christian ; Zhang, Xiaonan ; Schalke, Berthold ; Lee, De-Hyung ; Bulut, Elena ; Graeter, Thomas ; Ott, German ; Kurz, Katrin S. ; Preissler, Gerhard ; Schölch, Sebastian ; Farhat, Joviana ; Yao, Zhihan ; Sticht, Carsten ; Ströbel, Philipp ; Hergenröder, Roland ; Marx, Alexander ; Belharazem, Djeda



Zusammenfassung

Simple Summary Thymomas and thymic carcinomas (TCs) are malignant thymic epithelial tumors (TETs) with poor outcome, if non-resectable. Metabolic signatures of TETs have not yet been studied and may offer new therapeutic options. This is the first metabolomics investigation on thymic epithelial tumors employing nuclear magnetic resonance spectroscopy of tissue samples. We could detect and ...

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