Staphylococcus aureus Panton-Valentine Leukocidin worsens acute implant-associated osteomyelitis in humanized BRGSF mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-579956
DOI to cite this document:: 10.5283/epub.57995

Hofstee, Marloes I. ; Siverino, Claudia ; Saito, Motoo ; Meghwani, Himanshu ; Tapia-Dean, James ; Arveladze, Samson ; Hildebrand, Maria ; Rangel-Moreno, Javier ; Riool, Martijn

; Zeiter, Stephan ; Zaat, Sebastian A. J. ; Moriarty, T. Fintan ; Muthukrishnan, Gowrishankar

License: Creative Commons Attribution 4.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 27 Mar 2024 06:34

Alternative links to fulltext:DOI Publisher

Details

Preview

Export bibliographical data

Abstract

Staphylococcus aureus is the most common pathogen that causes implant-associated osteomyelitis, a clinically incurable disease. Immune evasion of S. aureus relies on various mechanisms to survive within the bone niche, including the secretion of leukotoxins such as Panton-Valentine leukocidin (PVL). PVL is a pore-forming toxin exhibiting selective human tropism for C5a receptors (C5aR1 and C5aR2) ...