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Solution structure and pressure response of thioredoxin-1 of Plasmodium falciparum

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Barnwal, Ravi Pratap ; Munte, Claudia Elisabeth ; Kalbitzer, Hans Robert
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Date of publication of this fulltext: 21 May 2024 15:50


We present here the solution structures of the protein thioredoxin-1 from Plasmodium falciparum (PfTrx-1), in its reduced and oxidized forms. They were determined by high-resolution NMR spectroscopy at 293 K on uniformly 13C-, 15N-enriched, matched samples allowing to identification of even small structural differences. PfTrx-1 shows an α/β-fold with a mixed five-stranded β-sheet that is ...


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