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Local and global effects of sedation in resting-state fMRI: a randomized, placebo-controlled comparison between etifoxine and alprazolam

URN to cite this document:
urn:nbn:de:bvb:355-epub-583708
DOI to cite this document:
10.5283/epub.58370
Wein, Simon ; Riebel, Marco ; Seidel, Philipp ; Brunner, Lisa-Marie ; Wagner, Viola ; Nothdurfter, Caroline ; Rupprecht, Rainer ; Schwarzbach, Jens V.
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
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Date of publication of this fulltext: 04 Jun 2024 05:42

This publication is part of the DEAL contract with Springer.


Abstract

TSPO ligands are promising alternatives to benzodiazepines in the treatment of anxiety, as they display less pronounced side effects such as sedation, cognitive impairment, tolerance development and abuse potential. In a randomized double-blind repeated-measures study we compare a benzodiazepine (alprazolam) to a TSPO ligand (etifoxine) by assessing side effects and acquiring resting-state fMRI ...

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