Surgical cytoreduction and hyperthermic intrathoracic chemotherapy for thymic tumours with pleural spread is effective on survival: results from the multicentre German hyperthermic intrathoracic chemotherapy study

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-586090 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.58609 Copy

Ried, Michael ; Hassan, Mohamed ; Passlick, Bernward ; Schmid, Severin ; Markowiak, Till ; Müller, Karolina ; Huppertz, Gunnar ; Koller, Michael ; Winter, Hauke ; Klotz, Laura V. ; Hatz, Rudolf ; Kovács, Julia ; Zimmermann, Julia ; Hofmann, Hans-Stefan ; Eichhorn, Martin E.

Lizenz: Creative Commons Namensnennung 4.0 International PDF - Veröffentlichte Version (958kB)

Veröffentlichungsdatum dieses Volltextes: 04 Jul 2024 10:30

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Details

Dokumentenart:	Artikel
Open Access Art:	Gold (mit APC - bezahlt UR)
Titel eines Journals oder einer Zeitschrift:	Interdisciplinary CardioVascular and Thoracic Surgery
Verlag:	OUP
Band:	36
Nummer des Zeitschriftenheftes oder des Kapitels:	6
Datum:	10 Februar 2023
Institutionen:	Medizin > Abteilung für Thoraxchirurgie
Identifikationsnummer:	Wert Typ 10.1093/icvts/ivad032 DOI
Stichwörter / Keywords:	Hyperthermic intrathoracic chemotherapy • Hyperthermic intrathoracic chemotherapy • Thymic tumour • Thymic carcinoma • Cytoreductive surgery
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Ja
Dokumenten-ID:	58609

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Zusammenfassung

OBJECTIVES Cytoreductive surgery and hyperthermic intrathoracic chemotherapy (HITOC) is effective on survival for patients with pleural metastatic thymic tumours. METHODS Multicentre, retrospective analysis of patients with stage IVa thymic tumours treated with surgical resection and HITOC. Primary end point was overall survival, secondary end points were recurrence-/progression-free ...

Zusammenfassung

OBJECTIVES

Cytoreductive surgery and hyperthermic intrathoracic chemotherapy (HITOC) is effective on survival for patients with pleural metastatic thymic tumours.
METHODS

Multicentre, retrospective analysis of patients with stage IVa thymic tumours treated with surgical resection and HITOC. Primary end point was overall survival, secondary end points were recurrence-/progression-free survival and morbidity/mortality.
RESULTS

A total of n = 58 patients (thymoma, n = 42; thymic carcinoma, n = 15; atypical carcinoid of the thymus, n = 1) were included, who had primary pleural metastases (n = 50; 86%) or pleural recurrence (n = 8; 14%). Lung-preserving resection (n = 56; 97%) was the preferred approach. Macroscopically complete tumour resection was achieved in n = 49 patients (85%). HITOC was performed with cisplatin alone (n = 38; 66%) or in combination with doxorubicin (n = 20; 34%). Almost half of the patients (n = 28; 48%) received high-dose cisplatin > 125 mg/m2 body surface area. Surgical revision was required in 8 (14%) patients. In-hospital mortality rate was 2%. During follow-up, tumour recurrence/progression was evident in n = 31 (53%) patients. Median follow-up time was 59 months. The 1-, 3- and 5-year survival rates were 95%, 83% and 77%, respectively. Recurrence/progression-free survival rates were 89%, 54% and 44%, respectively. Patients with thymoma had significantly better survival compared to patients with thymic carcinoma (P-value ≤0.001).
CONCLUSIONS

Promising survival rates in patients with pleural metastatic stage IVa in thymoma (94%) and even in thymic carcinoma (41%) were achieved. Surgical resection and HITOC is safe and effective for treatment of patients with pleural metastatic thymic tumours stage IVa.

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